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Vol 48(2014) N 1 p. 52-57; DOI 10.1134/S0026893314010099  V.I. Loginov1,5*, M.V. Atkarskaya2, A.M. Burdennyy 1,2**, T.M. Zavarykina2, T.P. Kazubskaya3, V.V. Nosikov2,5, E.A. Braga4,5, G.P. Zhizhina 2 Association of Arg72Pro of TP53 and T309G of MDM2 Genes Polymorphisms with Non-Small-Cell Lung Cancer in Russians of the Moscow Region 1Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, 125315, Russia2Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, 119334, Russia 3Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, 115478, Russia 4Research Center of Medical Genetics, Russian Academy of Medical Sciences, Moscow, 115478, Russia 5GosNIIgenetika State Research Center, Moscow, 117545, Russia *loginov7@genetika.ru **burdennyy@gmail.com Received - 2013-05-17; Accepted - 2013-07-04 Association of ТР53 Arg72Pro and MDM2 T309G polymorphic markers with the risk of non-small-cell lung cancer was studied in a Russian population of the Moscow region. The minor Pro/Pro genotype of Arg72Pro and the TG genotype of T309G were associated with non-small-cell lung cancer (OR = 5.46, p = 8 х 10-6 and OR = 7.38, p = 0.0001, respectively). Both Pro/Pro and TG genotypes were also strongly associated with lung adenocarcinoma (OR = 8.71, p = 3 х 10-6 and OR = 8.13, p = 0.003, respectively) and squamous-cell lung carcinoma (OR = 4.2, p = 0.001 and OR = 7.02, p = 0.002, respectively). Finally, combined susceptible genotypes of ТР53 and MDM2 polymorphisms Arg72Pro and T309G were reliably associated with non-small-cell lung cancer and both its subtypes (OR = 7.9, p = 0.01; OR = 9.12, p = 0.02; OR = 7.31, p = 0.03, respectively). Arg72Pro and T309G polymorphic markers, TP53, MDM2, non-small-cell lung cancer, adenocarcinoma, squamous-cell lung carcinoma |
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