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Vol 49(2015) N 2 p. 171-178; DOI 10.1134/S0026893315020028  F.L. Bai1,2, H. Tian2, Q.Z. Yu3, G.P. Ren1, D.S. Li1* Expressing foreign genes by Newcastle disease virus for cancer therapy 1College of Life Science, Northeast Agricultural University, Harbin, 150030 China2Research and Development Department, Lubin Environmental Equipment Protection Co., Ltd, Shanghai, 200125 China 3Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, 934 College Station Road, Athens, GA, 30605 USA *desganli@163.com Received - 2014-06-07; Accepted - 2014-07-31 An interesting aspect of Newcastle disease virus (NDV) is the ability to selectively replicate in tumor cells. Recently, using reverse genetics technology to enhance the oncolytic properties and therapeutic potential of NDV for tumor therapy has become popular in immunocompetent carcinoma tumor models. Expressing foreign genes by recombinant NDV (rNDV-FG) has been shown to be more effective in cancer therapy in preclinical studies. This paper provides an overview of the current studies on the cytotoxic and anti-cancer effects of rNDV-FG via direct oncolysis and immune stimulation. Safety of rNDV-FG as a therapeutic agent for cancer immunotherapy and virotherapy is also discussed. rNDV-FG, cancer therapy, cancer immunotherapy, virotherapy |
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