Journal of Molecular Biology

Year	IMPACT-FACTOR
2023	1,500
2022	1,200
2021	1,540
2020	1,374
2019	1,023
2018	0,932
2017	0,977
2016	0,799
2015	0,662
2014	0,740
2013	0,739
2012	0,637
2011	0,658
2010	0,654
2009	0,570
2008	0,849
2007	0,805
2006	0,330
2005	0,435
2004	0,623
2003	0,567
2002	0,641
2001	0,490
2000	0,477
1999	0,762
1998	0,785
1997	0,507
1996	0,518
1995	0,502

Vol 46(2012) N 2 p. 175-182;

K.S. Pougach^1,2*, A.V. Lopatina^1,2, K.V. Severinov^1,2

CRISPR Adaptive Immunity Systems of Prokaryotes
¹nstitute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia
²Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182 Russia

^*xeniklalt@gmail.com
Received - 2011-08-25; Accepted - 2011-10-14

CRISPR (clustered regularly interspaced short palindromic repeats) systems were found in the genomes of many eubacteria and the vast majority of archaea. Their unique feature is that CRISPR-mediated immunity is adaptive and can be programmed to protect cells against mobile genetic elements. The review describes the general principles of CRISPR-mediated immunity and characterizes the CRISPR systems of various microorganisms.

CRISPR systems, Cas proteins, small RNAs, adaptive immunity