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Vol 52(2018) N 2 p. 182-189; DOI 10.1134/S0026893317050211  O.V. Iarovaia1,2,4*, E.S. Ioudinkova1,2,4, S.V. Razin1,2,3, Y.S. Vassetzky2,3,4 Role of the Nucleolus in Rearrangements of the IGH Locus 1Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia2LIA1066 "Laboratoirefranco-russe de recherche en oncologie", Villejuif, France 3Biological Faculty, Moscow State University, Moscow, 119991 Russia 4CNRS UMR8126, Universite Paris Sud 11, Institut de Cancerologie Gustave Roussy, Villejuif, F-94805 France *iarovaia@inbox.ru Received - 2017-01-18; Accepted - 2017-02-09 The review summarizes the results from a series of studies focusing on the role that the nucleolus plays in maturation of the IGH locus and the choice of its partner genes in leukemia-associated translocations. The role of nuclear compartmentalization and nuclear localization of translocated oncogenes in ectopic activation of their transcription is discussed. compartmentalization of the nucleus, spatial organization of the genome, IGH locus, leukemia-associated translocations |
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