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Vol 45(2011) N 4 p. 686-690; Zhuang Cui1, Jun Wang2, Hui Liang2, Fang Zheng3, Bao-Li Wang2, Meng Mi4, Xiao-Xia Li5* High level secretory expression of murine OCIL by CHO cells and action of OCIL on osteoclast differentiation 1College of Public Health, Tianjin Medical University, Tianjin, 300070, China2Key Lab of Ministry of Health for Hormone and Development, Tianjin Medical University Institute of Endocrinology, Tianjin, 300070, China 3College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China 4Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, 410008, China 5Tianjin Medical University School of Basic Science, Tianjin, 300070, China *lixx@tijmu.edu.cn Received - 2010-09-07; Accepted - 2010-10-07 Receptor activator of nuclear factor-kB ligand (RANKL), a well-known membrane-bound molecule expressed on osteoblasts and bone marrow stromal cells, is believed to induce osteoclast differentiation and activation by binding to the receptor activator of nuclear factor-kB (RANK), which is expressed on the surface of osteoclast lineage cells. This induction is inhibited by osteoprotegerin (OPG) that is secreted by osteoblast lineage and acts as a decoy receptor of RANKL. Currently the essential role of the OPG/RANKL/RANK system in the process of osteoclast maturation, as well as activation, has been well established, and the majority of bone resorption regulators control osteoclast formation and activation through their effects on this system and especially on the relative expression levels of RANKL and OPG [1]. nuclear factor-kB, osteoprotergin, osteoclast inhibitory lectin |
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