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Vol 47(2013) N 6 p. 821-826; T.O. Abramova1, O.E. Redina1,2, S.E. Smolenskaya1, A.L. Markel1,2,3 Elevated Expression of the Ephx2 mRNA in the Kidney of Hypertensive ISIAH Rats 1Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090 Russia2Institute of Physiology and Fundamental Medicine, Siberian Branch, Russian Academy of Medical Sciences, Novosibirsk, 630090 Russia 3Novosibirsk State University, Novosibirsk, 630090 Russia *smallynx@ngs.ru Received - 2013-03-11; Accepted - 2013-06-26 Epoxyeicosatrienoic acids (EETs) have antihypertensive properties and play a role in maintaining the renal microvascular function. EETs mediate vasodilation of rat preglomerular microvessels and activate ion channels. Ephx2 codes for a soluble epoxide hydrolase (sEH), which catalyzes EET degradation. The renal cortex and medulla were tested for Ephx2 mRNA level in ISIAH rats with hereditary stress-sensitive hypertension and in normotensive WAG rats at rest and in emotional stress. Ephx2 transcriptional activity in ISIAH rats was significantly higher than in WAG rats at rest and in stress by both microarray analysis and real-time PCR. The results implicated Ephx2 in controlling and modulating the vascular tone in the kidney in both hypertensive ISIAH and normotensive WAG rats. Ephx2 mRNA, emotional stress, hypertension, kidney, ISIAH rats |
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