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Vol 44(2010) N 4 p. 541-545; Y.V. Agapkina1, A.G. Nikitin1, A.N. Brovkin1, A.A. Pushkov1, M.A. Evdokimova2, O.Y. Aseycheva2, V.S. Osmolovskaya2, L.O. Minushkina2, M.S. Kochkina2, N.D. Selezneva2, E.N. Dankovtseva2, O.S. Chumakova2, T.N. Baklanova3, P.A. Talyzin3, N.E. Reznichenko3, O.P. Donetskaya4, S.N. Tereschenko5, E.S. Krasilnikova5, N.A. Dzhaiani5, E.V. Akatova5, M.G. Glezer6, A.S. Galyavich7, V.B. Zakirova7, N.A. Koziolova8, I.V. Timofeeva8, M.A. Yagoda9, O.I. Boyeva9, L.I. Katelnitskaya10, E.V. Horolets10, S.V. Shlyk10, E.G. Volkova11, M.P. Margaryan11, I.O. Guz11, V.O. Konstantinov12, A.N. Timofeyeva12, B.A. Sidorenko2, D.A. Zateyshchikov2, V.V. Nosikov1* Association of the Polymorphic Markers G(--455)A in the FGB Gene and C(--1654)T in the PROC Gene with Hereditary Predisposition to Severe Ischemic Heart Disease in Patients with Histories of Acute Coronary Syndrome 1State Research Center GosNIIGenetika, Moscow, 1175452Medical Academic and Research Center, Administrative Department of the President of the Russian Federation, Moscow, 121359 3Municipal Hospital no.17, Moscow, 119620 4Clinical Hospital no.1, Administrative Department of the President of the Russian Federation, Moscow, 107143 5Moscow State University of Medicine and Dentistry, Moscow, 127473 6Sechenov Moscow Medical Academy, Moscow, 119021 7Kazan State Medical University, Kazan, 420012 8Vagner Perm State Medical Academy, Perm, 614000 9Stavropol State Medical Academy, Stavropol, 355014 10Rostov State Medical University, Rostov-on-Don, 344022 11Chelyabinsk State Medical Academy, Chelyabinsk, 454092 12Saint Petersburg State Mechnikov Medical Academy, St. Petersburg, 195067, Russia *nosikov@genetika.ru Received - 2009-09-29; Accepted - 2009-10-27 Associations of polymorphisms of genes FGB G(--455)A and PROC C(--1654)T with the frequency of poor outcomes in patients with the history of acute coronary syndrome (ACD) were studied in the Russian population. A total of 1145 patients admitted to cardiological hospitals of Moscow, St. Petersburg, Kazan, Chelyabinsk, Perm, Stavropol, and Rostov-on-Don with ischemic heart disease exacerbation were examined. The mean supervision term was 1.14 + 0.33 yr, and the maximum term was 3.2 yr. The risk of poor outcome did not depend on the carriership of genotypes of the polymorphic G(--455)A marker in the FGB gene. However, the PROC C(--1654)T polymorphism patients with ACD history and allele Т of the PROC gene had a poor outcome more often than patients homozygous for allele C. The survival time to the endpoint for carriers of the TT and CT genotypes of the PROC gene was 2.19 + 0.18 yr vs. 2.46 + 0.16 yr for carriers of the CC genotype. On the base of these results it is suggested that hemostasis-related genes play an important role in early failures in patients with ACD history. acute coronary syndrome, poor outcomes, polymorphic markers G(-455)A of the FGB gene and C(-1654)T of the PROC gene, survival rate, multicenter study |
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