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Vol 44(2010) N 3 p. 369-379; D. Baskaran, P.V. Spirin, V.S. Prasolov* Activated Leukemic Oncogenes Responsible for Neoplastic Transformation of Hematopoietic Cells Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia*prasolov@eimb.ru Received - 2009-09-30; Accepted - 2009-12-03 Leukemias are a heterogeneous group of malignant blood diseases that are characterized by expansion of immature blast cells. The point molecular mechanisms of leukemogenesis are still unknown. Leukemia patients frequently have mutations of the genes responsible for normal proliferation and differentiation of hematopoietic stem cells. At present, scientific groups worldwide are engaged in biomedical studies of the structural and functional aspects of leukemic oncogenes and their role in human and animal leukemogenesis. The review describes the current concepts of the molecular properties of oncogenes whose activation may lead to CBF-AML, which results from mutations of the genes for the core binding factors AML1 (CBFα) and CBFβ. leukemia, neoplastic transformation of cells, gene expression, acute myeloid leukemia, hematopoiesis, point mutations, deletions, insertions, inversions, translocations, chromosomal aberrations |
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