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Vol 47(2013) N 5 p. 622-633; E.S. Marakasova1,2, N.K. Akhmatova1, M. Amaya2, B. Eisenhaber3,4,5, F. Eisenhaber4, M.L. van Hoek2, A.V. Baranova2,6* Prenylation: From Bacteria to Eukaryotes 1Mechnikov Research Institute for Vaccines and Sera, Russian Academy of Medical Sciences, Moscow, 105064 Russia2Сenter for the Study of Chronic Metabolic Diseases and School of Systems Biology, David King Hall, George Mason University, Fairfax, 22030, USA 3School of Computer Engineering, Nanyang Technological University, 637553, Singapore 4Bioinformatics Institute, Agency for Science, Technology and Research, 138671, Singapore 5Department of Biological Sciences, National University of Singapore, 117597, Singapore 6Research Centre for Medical Genetics, Russian Academy of Medical Sciences, Moscow, 115478 Russia *aancha@gmail.com Received - 2013-02-08; Accepted - 2013-04-18 For their protection from host cell immune defense, intracellular pathogens of eukaryotic cells developed a variety of mechanisms, including secretion systems III and IV which can inject bacterial effectors directly into eukaryotic cells. These effectors may function inside the host cell and may be posttranslationally modified by host cell machinery. Recently, prenylation was added to the list of possible posttranslational modifications of bacterial proteins. In this work we describe the current state of the knowledge about the prenylation of eukaryotic and prokaryotic proteins and prenylation inhibitors. The bioinformatics analyses suggest the possibility of prenylation for a number of Francisella genus proteins. prenylation, mechanism, PrePS, prenylation inhibitors, Francisella, SifA, AnkB proteins |
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