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Vol 47(2013) N 5 p. 605-612; G.B. Zavilgelsky 60 Years of SOS Repair State Research Center GosNIIGenetika, Moscow, 117545 Russia*zavilgel@genetika.ru Received - 2013-04-08; Accepted - 2013-04-11 This review integrates 60 years of research on SOS repair and SOS mutagenesis in prokaryotes and eukaryotes, from Jean Weigle's experiment in 1953 (mutagenesis of lambda bacteriophage in UV-irradiated bacteria) to the latest achievements in studying SOS mutagenesis on all living organisms, i.e., Eukarya, Archaea and Bacteria. A key role in establishing of a biochemical basis for SOS mutagenesis belongs to the finding in 1998-1999 that specific error-prone DNA polymerases (PolV and others) catalyzed translesion synthesis on damaged DNA. This review focuses on recent studies that address new models for SOS-induced mutagenesis in Escherichia coli and Homo sapiens cells. SOS repair, SOS mutagenesis, translesion synthesis, umuC, umuD, DNA polymerase, Y family, RecA, pyrimidine dimer, AP site, Xeroderma pigmentosum |
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