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Vol 44(2010) N 1 p. 23-27; S.V. Buikin1*, M.V. Golubenko1, V.P. Puzyrev1,2 Genes for Mitochondria in Arterial Hypertension and Left Ventricular Hypertrophy 1Institute of Medical Genetics, Tomsk Research Center, Siberian Division, Russian Academy of Medical Sciences, Tomsk, 634050, Russia2Russian Ministry of Health and Social Development, Siberian State Medical University, Tomsk, 634050, Russia *stepan.buikin@medgenetics.ru Received - 2009-06-24; Accepted - 2009-07-09 Study is devoted to "genes for mitochondria" - genes of mitochondrial genome and mitochondrial DNA polymerase γ gene (POLG1). We com pared frequencies of polymorphisms in mitochondrial DNA and in POLG1 between healthy individuals and patients with arterial hypertension, as well as between patients with and without left ventricular hypertrophy. We did not discover significant differences of distribution of C allele of MspIpolymorphism in POLG1 in studied group. We have shown higher prevalence of mitochondrial haplogroup H of mtDNA in patients without left ventricle hypertrophy (OR = 0.42; 95%CI 0.17-0.98; р = 0.043), while compared with patients having this complication. Haplogroup T was more fre quently detected in patients with left ventricle hypertrophy (OR = 6.16; 95%CI 1.17-9.74; р = 0.018). This result sug gest implication of mitochondrial DNA in hypertensioninduced left venticular hypertrophy. arterial hypertension, left ventricular hypertrophy, analysis of association, common disease, mtDNA, POLG1 |
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