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Vol 50(2016) N 3 p. 344-352; DOI 10.1134/S0026893316020187  N.N. Orlova, T.D. Lebedev, P.V. Spirin, V.S. Prassolov* Key molecular mechanisms associated with cell malignant transformation in acute myeloid leukemia Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia*prassolov45@mail.ru Received - 2015-09-29; Accepted - 2015-10-20 Cancer, along with cardiovascular disorders, is one of the most important problems of healthcare. Pathologies of the hematopoietic system are the most prevalent in patients under 30 years of age, including acute myeloid leukemia (AML), which is widespread and difficult to treat. The review considers the mechanisms that play a significant role in AML cell malignant transformation and shows the contributions of certain genes to both remission and resistance of AML cells to various treatments. acute myeloid leukemia, cancer, signaling pathways, apoptosis, DNA repair, JNK, TGF-β, p38, Hedgehog |
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