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Vol 45(2011) N 1 p. 139-149; A.B. Chetverin* Paradoxes of Replication of RNA of a Bacterial Virus Institute of Protein Reseach, Russian Academy of Sciences, Pouschino, 142290 Russia*alexch@vega.protres.ru Received - 2010-07-26; Accepted - 2010-07-26 The extraordinary ability of the bacteriophage Q replicase to amplify RNA outside the cell attracted the attention of molecular biologists in the late 1960s-early 1970s. However, at that time, a number of puzzling properties of the enzyme was not explained. Not until recently has Q replicase begun to reveal its secrets, promising to give a key not only to understanding the mechanism of replication of the bacterial virus genome but also to the solution of more general fundamental and applied problems. RNA-dependent RNA polymerase, proteins of the translation apparatus, exponential amplification of RNA, terminal adenylylation, spontaneous RNA synthesis, template specificity, replicative intermediate |
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