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Vol 42(2008) N 2 p. 321-327;
M.V. Penkina1, O.I. Karpova1,2, N.V. Zakharevich2, T.V. Sizova1, Yu.F. Bogdanov1

SCAR DNA family is enriched in evolutionarily conserved sequences

1Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russia
2Moscow State University, Moscow, 119992, Russia
Received - 2007-10-04; Accepted - 2007-10-15

The family of DNA sequences tightly associated with the synaptonemal complex (SC), or SCAR DNA family, has earlier been described as a specific family of golden hamster genomic DNA sequences. DNA sequences similar to golden hamster SCAR DNA proved to be widespread in the genomes of some vertebrates. A comparison with a sample of random sequences showed that the SCAR DNA family is enriched in evolutionarily conserved sequences, which correlates with the universal SC morphology and processes occurring in meiotic prophase I.

Meiosis, synaptonemal complex, SCAR DNA, evolutionary conservation
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