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Vol 47(2013) N 3 p. 343-351; A.V. Shaposhnikov*, I.F. Komar'kov, L.A. Lebedeva, Y.V. Shidlovskii Molecular Components of JAK/STAT Signaling Pathway and Its Interaction with Transcription Machinery Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia*shaldr23@mail.ru Received - 2012-12-26; Accepted - 2013-01-18 JAK/STAT is a conserved signaling pathway in higher eukaryotes that plays a critical role in different processes of ontogenesis. This article reviews the pathway structure at the molecular level, mainly in Drosophila as a model organism. The review is focused on the data concerning the relationship between this signaling pathway and transcription machinery of higher eukaryotes. signaling pathways, JAK/STAT, transcription factors, eukaryotes |
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