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Vol 49(2015) N 6 p. 881-889; DOI 10.1134/S0026893315060047  A.A. Cherednichenko1,2*, E.A. Trifonova1,2, K.V. Vagaitseva1,2, A.V. Bocharova2, A.M. Varzari3, M.O. Radzhabov4,5, V.A. Stepanov1,2 Prevalence of gene polymorphisms associated with immune disorders in populations of Northern Eurasia 1National Research Tomsk State University, Tomsk, 634050 Russia;2Research Institute for Medical Genetics, Tomsk, 634050 Russia 3Chiril Draganiuc Institute of Phthisiopulmonology, Chisinau, MD 2025, Republic of Moldova 4Analytical Center for Collective Use, Dagestan Scientific Center, Russian Academy of Sciences, Makhachkala, 367001 Russia 5Dagestan Medical Dental Institute, Makhachkala, 367015 Russia *anastasia.cherednichenko@medgenetics.ru Received - 2015-03-11; Accepted - 2015-05-15 Allele-frequency distributions for gene polymorphisms associated with autoimmune and allergic diseases, as well as the regulation of immunoglobulin E and cytokines levels, were studied in 26 populations of Northern Eurasia. There was no significant correlation between the values of average expected heterozygosity by 44 gene polymorphisms and climate or geographic factors. Population groups exhibited clustering according to their geographic location. The degree of genetic differentiation among populations and the selective neutrality of gene polymorphisms were also assessed. The results demonstrate substantial genetic diversity and differentiation of human populations by the genes studied. single nucleotide polymorphisms, populations of Northern Eurasia, genetic diversity, immune disorders, climate and geographic factors |
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