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Vol 48(2014) N 4 p. 590-593; DOI 10.1134/S0026893314040074  O.I. Mozhey1,3, P.A. Zatolokin2, M.A. Vasilenko3, L.S. Litvinova3, E.V. Kirienkova1,3, I.O. Mazunin1,3* Evaluating the Number of Mitochondrial DNA Copies in Leukocytes and Adipocytes from Metabolic Syndrome Patients: Pilot Study 1Medical Institute, Immanuel Kant Baltic Federal University, Kaliningrad, 236016 Russia2Department of Reconstructive and Endoscopic Surgery, Kaliningrad Regional Hospital, Kaliningrad, 236016 Russia 3Innovation Park, Immanuel Kant Baltic Federal University, Kaliningrad, 236016 Russia *IMazunin@kantiana.ru Metabolic syndrome is a complex of metabolic, hormonal, and clinical disorders. Defects in mitochondrial functions play an important role in the metabolic syndrome pathogenesis. Here, variations in the number of mitochondrial DNA (mtDNA) copies were evaluated in different fat-tissue and peripheral-blood-leukocyte samples from metabolic syndrome patients ranked by body mass indices. The number of mtDNA copies showed a tendency to decrease with increase body mass index. metabolic syndrome, body mass index, mitochondrial DNA number of copies, adipocytes |
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