|
Vol 43(2009) N 6 p. 961-967; Yu.Yu. Fedorova1, O.A. Gra4, A.S. Karunas1, A.Kh. Khuzina1, N.N. Ramazanova2, A.A. Yuldasheva3, A.R. Biktasheva2, E.I. Etkina2, T.V. Nasedkina5, I.V. Goldenkova-Pavlova4, E.K. Khusnutdinova1 Association of polymorphisms of xenobiotic metabolism genes with childhood atopic diseases in Russian patients from Bashkortostan 1Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Sciences, Ufa, 450054, Russia2Bashkir State Medical University, Ufa, 450000, Russia 3Pediatric Outpatient Center No. 1, Ufa, 450000, Russia 4Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russia 5Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia Received - 2008-12-29; Accepted - 2009-03-18 Biotransformation enzymes involved in the metabolism of exogenous and endogenous compounds efficiently protect the organism from harmful environmental factors. Decreased activity or insufficient synthesis of biotransformation enzymes due to genetic polymorphism is a risk factor for various complex diseases, including atopy. Allele-specific hybridization on a biochip was used to evaluate the frequencies of xenobiotic metabolism gene polymorphisms in children with bronchial asthma and/or allergic rhinitis and in healthy donors, all residents of the Republic of Bashkortostan of Russian descent. Polymorphisms of CYP1A1, GSTT1, GSTM1, NAT2, MTHFR, CYP2C9, and CYP2C19 were not associated with atopic diseases in children. The genotype CYP2D6*1934G/G and the allele CYP2D6*1934G were associated with an increased risk of allergic rhinitis in boys. bronchial asthma, allergic rhinitis, polymorphism, association, oligonucleotide biochip, xenobiotic metabolism genes, children |
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
