JMB-HEADER RAS-JOURNALS EIMB Pleiades Publishing

RUS

             

ENG

YearIMPACT-FACTOR
2022  1,200
2021  1,540
2020  1,374
2019  1,023
2018  0,932
2017  0,977
2016  0,799
2015  0,662
2014  0,740
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 43(2009) N 4 p. 586-590;
V.A. Furalyov, I.V. Kravchenko, V.O. Popov

Small interfering RNA targeting the human myostatin gene

Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, 119071, Russia
Received - 2009-01-12; Accepted - 2009-01-30

Ten small interfering RNA to human myostatin gene, selected with two different software programs, were synthesized and tested. Three of them exhibited pronounced biological activity and reduced the amount of myostatin mRNA to 22-27%, compared to control level. These small interfering RNAs stimulated the proliferation of human myoblasts and hindered their differentiation. The obtained small interfering RNAs can be used for the development of new approaches in the therapy of sarcopenia and various myodystrophies.

Myostatin, siRNA, RNA-interference, myoblasts



JMB-FOOTER RAS-JOURNALS