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Vol 53(2019) N 6 p. 889-895; DOI 10.1134/S0026893319060025 Full Text

A.V. Belyavsky1*

Niches of Hematopoietic Stem Cells in Bone Marrow

1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia

*abelyavs@yahoo.com
Received - 2018-12-03; Revised - 2019-04-04; Accepted - 2019-04-08

Hematopoietic stem cells (HSCs) exist in a close contact with their specific microenvironment, called a niche, which supports the HSC function and significantly influences the HSC properties. The existence of the HSC niche, which was proposed as a purely theoretical concept in 1978, finds increasing experimental evidence and is now generally accepted by specialists in the field of hematopoiesis. The review briefly describes various cell components of the HSC niche in bone marrow, considers the metabolic states of the niche and HSCs, and discusses other aspects of niche biology. Increasing knowledge of the HSC niche will help to create in vitro cell models of the HSC niche, to modulate the HSC properties, and to achieve multifold HSC expansion in culture for further applications in therapeutic practice.

hematopoietic stem cells, progenitor cells, niche, perivascular cells, endothelium, mesenchymal stem cells, arteriole, sinusoid



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