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Vol 53(2019) N 2 p. 308-311; DOI 10.1134/S0026893319020043 Full Text

A.V. Finkelstein1,2*, L.P. Gavrilova1

Protein Biosynthesis Proofreading Is Closely Associated with the Existence of Factor-Free Ribosomal Synthesis

1Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290 Russia
2Faculty of Biology, Moscow State University, Moscow, 119991 Russia

*afinkel@vega.protres.ru
Received - 2018-07-19; Revised - 2018-08-14; Accepted - 2018-08-16

Despite protein biosynthesis being studied for decades, some major questions concerning this process are still to be addressed. We elucidate a close connection between proofreading of the emerging amino acid sequence during its normal, elongation factor-dependent ribosomal biosynthesis and the existence of the factor-free synthesis of a polypeptide chain on a ribosome. In this factor-free process, the biological role of proofreading is played by a process opposite to the factor-free attachment of Aa-tRNA to the ribosome, namely, the removal via the same pathway of that Aa-tRNA, which is not complementary to the mRNA codon exhibited by the ribosome.

biosynthesis of polypeptides, ribosome, elongation factor Tu, GTP, factor-free process, parallel reactions, free energy, codon recognition, proofreading



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