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Vol 43(2009) N 1 p. 159-165; E.S. Piruzian1, A.A. Ishkin1,2, T.A. Nikol\'skaya1,2, R.M. Abdeev3, S.A. Bruskin1 A comparative analysis of the molecular genetic processes in the pathogenesis of psoriasis and Crohn\'s disease 1Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russia2GeneGo, New York, USA 3Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow, 119991, Russia Received - 2008-04-30; Accepted - 2008-07-14 A comparative bioinformatics analysis of the molecular genetic processes in the pathogenesis of multifactorial diseases - psoriasis and Crohn\'s disease-was performed using the results of microarray experiments deposited with the GEO DataSets database. A number of genes and molecular genetic processes common to both pathologies were found. The involvement of several transcription factors, including AP-1 transcription factors, in the pathogeneses of both psoriasis and Crohn\'s disease was postulated. Psoriasis, Crohn\'s disease, gene networks, candidate genes, AP-1 |
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