JMB-HEADER RAS-JOURNALS EIMB Pleiades Publishing

RUS

             

ENG

YearIMPACT-FACTOR
2022  1,200
2021  1,540
2020  1,374
2019  1,023
2018  0,932
2017  0,977
2016  0,799
2015  0,662
2014  0,740
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 49(2015) N 4 p. 598-607; DOI 10.1134/S0026893315040160 Full Text

O.A. Simonova1, E.B. Kuznetsova1,2, E.V. Poddubskaya3, T.V. Kekeeva1, R.A. Kerimov3, I.D. Trotsenko4, A.S. Tanas1,2,5, V.V. Rudenko1,2, E.A. Alekseeva1,2, D.V. Zaletayev1,2,5, V.V. Strelnikov1,2,5*

DNA methylation in the promoter regions of the laminin family genes in normal and breast carcinoma tissues

1Research Centre for Medical Genetics, Moscow, 115478 Russia
2Sechenov First Moscow State Medical University, Moscow, 199991 Russia
3Blokhin Russian Research Center for Oncology, Moscow, 115478 Russia
4Peoples' Friendship University of Russia, Moscow, 117198 Russia
5Pirogov Russian National Research Medical University, Moscow, 117997 Russia

*vstrel@list.ru
Received - 2014-10-10; Accepted - 2015-01-26

Extracellular glycoproteins of the laminin family are essential components of basement membranes involved in a number of biological processes, including tissue differentiation, wound healing, and tumorigenesis. We present the first comprehensive study of promoter methylation status of the genes encoding laminin chains in normal tissues (peripheral blood leucocytes, buccal epithelial cells, autopsy breast tissue samples) and in breast carcinoma samples. Based on the results of this study, we divide laminin genes into three categories. Genes, constitutively methylated in breast tissues include LAMA3A, LAMB2, LAMB3, and LAMC2. Genes prone to abnormal methylation in breast carcinoma include LAMA1, LAMA2, LAMA3B, LAMA4, LAMB1, and LAMC3. Genes that are rarely if ever methylated in breast carcinoma include LAMA5 and LAMC1. The constitutively methylated group includes all of the genes that encode subunits of laminin-5 (the historical name of laminin 332), the promoters of which were previously considered unmethylated in normal tissues and prone to abnormal methylation in breast cancer.

laminin, breast cancer, DNA methylation



JMB-FOOTER RAS-JOURNALS