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Vol 49(2015) N 1 p. 103-111; DOI 10.1134/S0026893315010112  A.G. Nikitin1*, V.A. Potapov2, A.N. Brovkin1, E.Yu. Lavrikova1, D.S. Khodyrev1, M.Sh. Shamhalova3, S.A. Smetanina4, L.N. Suplotova4, M.V. Shestakova3, V.V. Nosikov1, A.V. Averyanov1 Association of FTO, KCNJ11, SLC30A8, and CDKN2B polymorphisms with type 2 diabetes mellitus 1Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies, Federal Medico-Biological Agency of Russia, Moscow, 116682 Russia2Arkhimed Clinics of New Medical Technologies, Moscow, 129128 Russia 3Endocrinology Research Center, Moscow, 117036 Russia 4Tyumen State Medical Academy, Tyumen, 625023 Russia *avialn@gmail.com Received - 2014-07-28; Accepted - 2014-09-05 To test FTO, KCNJ11, SLC30A8, and CDKN2B for association with type 2 diabetes mellitus (DM), the allele and genotype frequency distributions were established for several polymorphisms of the genes. A comparison of allele and genotype frequencies between DM patients and healthy subjects implicated CKNJ11, SLC30A8, and CDKN2B, but not FTO, in the disease. The genes that affect insulin production and secretion in pancreatic β cells proved to play a main role in type 2 DM in the Russian population. type 2 diabetes mellitus, polymorphism, genetic predisposition |
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