JMB-HEADER RAS-JOURNALS EIMB Pleiades Publishing

RUS

             

ENG

YearIMPACT-FACTOR
2022  1,200
2021  1,540
2020  1,374
2019  1,023
2018  0,932
2017  0,977
2016  0,799
2015  0,662
2014  0,740
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 48(2014) N 6 p. 761-766; DOI 10.1134/S002689331406017X Full Text

J.-C. Tang, A.-Y. Xie, X.-J. Cai*

Diverse functions of fibulin-5 in tumor

Key Laboratory of Surgery of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, 310016 P. R. China

*cxjzu@hotmail.com
Received - 2014-03-05; Accepted - 2014-04-28

Altered interactions between the extracellular matrix and cells play an important part in tumorigenesis and metastasis. As a member of a matricellular glycoprotein, fibulin-5 is expressed in elastin-rich tissues and organizes the matrix structures by interacting with many extracellular proteins. Fibulin-5 expression is closely associated with normal embryonic development and organogenesis. Mice deficient for the fibulin-5 gene exhibit systemic elastic fiber defects with manifestation of loose skin, emphysematous lungs and tortuous vessels. Additionally, fibulin-5 null mice exhibited increased angiogenesis after wound healing or PVA sponge implantation and matrigel implantation experiments show that fibulin-5 inhibits vessel formation, suggesting its function as an angiogenesis inhibitor. Fibulin-5 also plays critical roles in proliferation, migration and invasion of certain tumors, and the effect of fibulin-5 on tumorigenesis appears to be largely context-dependent. This effect might involve the inhibiting action of fibulin-5 on angiogenesis. This review focuses on recent advances in our understanding of the roles of fibulin-5 in tumorigenesis: both tumor promoting and suppressing activities of fibulin-5 are reviewed, and the emerging evidence of its promising potential for therapeutic options and/or targets in the treatment of cancer is also highlighted.

fibulin-5, tumorigenesis, angiogenesis, cancer therapy



JMB-FOOTER RAS-JOURNALS