Vol 52(2018) N 3 p. 335-349; DOI 10.1134/S0026893318030068
O.I. Kiseleva*, A.V. Lisitsa, E.V. Poverennaya
Proteoforms: Methods of Analysis and Clinical ProspectsOrekhovich Institute of Biomedical Chemistry, Moscow, 119121 Russia
Received - 2017-07-04; Accepted - 2017-09-19
A critical analysis of proteomes provides a basis for understanding the operation of complex biochemical systems. A personalized approach to therapy takes into account biological uniqueness of each patient at genome, transcriptome, and proteome levels, and is a priority area in molecular medicine. The identification of proteoforms, which have dramatic impact on the phenotype of a disease, is a fundamental task of personal molecular profiling. Considerable progress of proteomic approaches presented new avenues for accurate, specific, and high-performance protein analysis. Thus, the identification of new efficient bio-markers can be expected based on studies of aberrant proteoforms associated with various diseases.
proteoforms, proteome heterogeneity, human proteome, biomarkers