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Vol 52(2018) N 2 p. 182-189; DOI 10.1134/S0026893317050211 Full Text

O.V. Iarovaia1,2,4*, E.S. Ioudinkova1,2,4, S.V. Razin1,2,3, Y.S. Vassetzky2,3,4

Role of the Nucleolus in Rearrangements of the IGH Locus

1Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia
2LIA1066 "Laboratoirefranco-russe de recherche en oncologie", Villejuif, France
3Biological Faculty, Moscow State University, Moscow, 119991 Russia
4CNRS UMR8126, Universite Paris Sud 11, Institut de Cancerologie Gustave Roussy, Villejuif, F-94805 France

*iarovaia@inbox.ru
Received - 2017-01-18; Accepted - 2017-02-09

The review summarizes the results from a series of studies focusing on the role that the nucleolus plays in maturation of the IGH locus and the choice of its partner genes in leukemia-associated translocations. The role of nuclear compartmentalization and nuclear localization of translocated oncogenes in ectopic activation of their transcription is discussed.

compartmentalization of the nucleus, spatial organization of the genome, IGH locus, leukemia-associated translocations



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