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Vol 51(2017) N 6 p. 813-818; DOI 10.1134/S0026893317060152 Full Text

N.E. Sharanova1,2, J. Ninnemann3, M.A. Bondareva1,2, Y.K. Semin1,2, A.V. Nomokonova1,2, A.A. Kruglov1,3*

Analysis of the Specificity of IgA Antibodies Produced in the Mouse Small Intestine

1Belozerskii Institute of Physico-Chemical Biology, Moscow State University, Moscow, 119991 Russia
2Immunology Department, Biological Faculty, Moscow State University, Moscow, 119991 Russia
3German Rheumatism Research Center (DRFZ), a Leibniz Institute, Berlin, 10117 Germany

*andrey_krugloff@mail.ru
Received - 2017-05-27; Accepted - 2017-07-21

Intestinal microbiota controls multiple aspects of body homeostasis. The microbiota composition changes easily in response to internal or external factors, which may result in dysbiosis and associated inflammatory reactions. Thus, maintaining the microbiota composition by the host immune system is crucial, and one of the main mechanisms for microbiota control is production of immunoglobulin A (IgA) at mucosal surfaces. The molecular mechanisms regulating the interactions between the immune system and microbiota remain obscure. A panel of hybridoma cell lines was constructed to produce monoclonal IgA antibodies specific to various commensal bacteria present in intestinal microbiota. The panel can be used to further understand the mechanisms whereby the adaptive immune system controls the microbiota composition.

immunoglobulin A, IgA, microbiota



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