JMB-HEADER RAS-JOURNALS EIMB Pleiades Publishing

RUS

             

ENG

YearIMPACT-FACTOR
2022  1,200
2021  1,540
2020  1,374
2019  1,023
2018  0,932
2017  0,977
2016  0,799
2015  0,662
2014  0,740
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 47(2013) N 6 p. 871-878;
Y.V. Gritsyna1, N.N. Salmov1, I.M. Vikhlyantsev1*, A.D. Okuneva 2, M.G. Sharapo3, V.V. Teplova1, Z.A. Podlubnaya1

Changes in Gene Expression and Titin (Connectin) Content in Striated Muscles of Chronically Alcoholized Rats

1Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Russia
2Pushchino State Institute of Natural Sciences , Pushchino, 142290 Russia
3Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, 142290 Russia

*vikhlyantsev@iteb.ru
Received - 2013-04-17; Accepted - 2013-05-25

Using the real-time reverse-transcription polymerase chain reaction (RT-PCR) and low percentage SDS-gel electrophoresis, changes in the gene expression and isoform composition of a giant sarcomeric protein titin (connectin) in cardiac muscle and changes in its isoform composition in skeletal muscle m. soleus of chronically alcoholized rats were studied. The decreased content of titin protein in examined muscles and decreases in titin gene expression in the myocardium of chronically alcoholized rats were found, which indicates the development of the pathological process.

titin isoforms, ttn gene, myosin heavy chains, striated muscles, chronically alcoholized rats



JMB-FOOTER RAS-JOURNALS