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Vol 42(2008) N 6 p. 911-916;
O.A. Kossinova, A.A. Malygin, E.S. Babailova, G.G. Karpova

Binding of human ribosomal protein p40 and its truncated mutants to the small ribosomal subunit

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia
Received - 2008-05-29; Accepted - 2008-05-26

Ribosomal protein SA (rpSA), or p40, is a structural element of the small subunit of the eukaryotic ribosome. The N-terminal and central parts of rpSA are homologous to prokaryotic S2, whereas its C-terminal part is specific to eukaryotes. Preparations of 40S ribosomal subunits isolated from full-term human placenta proved to be deficient in SA to a varying extent. To study the rpSA binding to human 40S subunits, recombinant rpSA and its mutant forms with N-and C-terminal deletions were synthesized. The full-size and N-truncated rpSA variants bound to 40S subunits, while deletion of the C-terminal domain completely abolished the binding.

ribosomal protein SA (p40), laminin-binding domain, 40S ribosomal subunit, RNA-protein interaction



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