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Vol 42(2008) N 2 p. 209-212; I.A. Goncharova1, E.V. Beloborodova2, M.B. Freidin1, E.I. Beloborodova2, G.E. Chernogoruk2, V.P. Puzyrev1,2 Genetic factors predisposing to a chronic course of virus hepatitis and liver fibrosis 1Institute of Medical Genetics, Tomsk Research Center, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, 634050, Russia2Siberian State Medical University, Tomsk, 634050, Russia Received - 2007-03-12; Accepted - 2007-11-12 The IL4 C(-590)T, IL4RA Ile50Val, and TNF G(-308)A polymorphisms were tested for association with the chronic development of virus hepatitis, the extent of which was inferred from the liver fibrosis stage. The frequency of allele A of the TNF G(-208)A polymorphism in patients with mild fibrosis was higher (24.5%) than in patients with moderate or severe fibrosis (13.4%) or cirrhosis (8.7%). The frequency of heterozygous genotype CT of the IL4 C(-590)T polymorphism significantly differed between cirrhosis (68.2%) and moderate or severe fibrosis (39.1%). chronic virus hepatitis, genetics of infectious diseases, genetic polymorphism, cytokine genes |
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