JMB-HEADER RAS-JOURNALS EIMB Pleiades Publishing

RUS

             

ENG

YearIMPACT-FACTOR
2022  1,200
2021  1,540
2020  1,374
2019  1,023
2018  0,932
2017  0,977
2016  0,799
2015  0,662
2014  0,740
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 49(2015) N 6 p. 796-809; DOI 10.1134/S0026893315060023 Full Text

M.T. Bondarenko1*, N.V. Maluchenko2, M.E. Valieva2, N.S. Gerasimova2, O.I. Kulaeva1,2, P.G. Georgiev3, V.M. Studitsky1,2**

Structure and function of histone chaperone FACT

1Fox Chase Cancer Center, Philadelphia, PA, 19111-2497 United States
2Biology Department, Moscow State University, Moscow, 119991 Russia;
3Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia

*bond4@mail.ru
**vasily.studitsky@fccc.edu
Received - 2015-04-15; Accepted - 2015-04-30

FACT is heterodimer protein complex and histone chaperone that plays an important role in maintaining and modifying the chromatin structure during various DNA-dependent processes. FACT is involved in nucleosome assembly de novo and in the preservation and recovery of the nucleosome structure during and after transcription, replication and DNA repair. During transcript elongation, FACT reduces the height of the nucleosome barrier and supports the maintenance of nucleosomes during and after the passage of RNA polymerase II. In this process, FACT interacts with histone H2A-H2B dimer within nucleosomes, thus, facilitating uncoiling of nucleosomal DNA from the octamer of histones. It also facilitates the subsequent recovery of the canonical nucleosome structure after transcription. FACT also plays an important role in the transformation of human cells and in maintaining the viability of tumor cells.

FACT, transcription, chromatin, histones H2A-H2B



JMB-FOOTER RAS-JOURNALS